With noninfectious liver diseases, substances accumulate in liver cells in abnormally large amounts. In nonalcoholic fatty liver disease, or NAFLD, fat buildup occurs within the liver cells. This increasingly common liver disease among Americans is frequently found in people with obesity and/or type 2 diabetes. Fat buildup within liver cells is also characteristic of early alcoholic liver disease. Abnormal buildup of iron within liver cells, such as with the hereditary disease called hemochromatosis, is another example of abnormal accumulation that can incite liver disease.